A 2x2 bit multiplier using hybrid 13t full adder with vedic mathematics method

Various arithmetic circuits such as multipliers require full adder (FA) as the main block for the circuit to operate. Speed and energy consumption become very vital in design consideration for a low power adder. In this paper, a 2x2 bit Vedic multiplier using hybrid full adder (HFA) with 13 transistors (13T) had been designed successfully. The design was simulated using Synopsys Custom Tools in General Purpose Design Kit (GPDK) 90 nm CMOS technology process. In this design, four AND gates and two hybrid FA (HFAs) are cascaded together and each HFA is constructed from three modules. The cascaded module is arranged in the Vedic mathematics algorithm. This algorithm satisfied the requirement of a fast multiplication operation because of the vertical and crosswise architecture from the Urdhva Triyakbyam Sutra which reduced the number of partial products compared to the conventional multiplication algorithm. With the combination of hybrid full adder and Vedic mathematics, a new combination of multiplier method with low power and low delay is produced. Performance parameters such as power consumption and delay were compared to some of the existing designs. With a 1V voltage supply, the average power consumption of the proposed multiplier was found to be 22.96 µW and a delay of 161 ps

A 4x4 Bit Vedic Multiplier with Different Voltage Supply in 90 nm CMOS Technology

In recent years, due to the rapid growth of high performance digital systems, speed and power consumption become very vital in multiplier design. In this paper, a 4x4 bit Vedic multiplier has been designed using the combination of Urdhva Triyakbyam Sutra and 13T hybrid full adder (HFA). This algorithm satisfied the requirement of a fast multiplication operation because of the vertical and crosswise architecture from the Urdhva Triyakbyam Sutra which minimize the number of partial products compared to the conventional multiplication algorithm. The multiplier is simulated using Synopsys Custom Tools with General Process Design Kit (GPDK) of 90 nm CMOS technology using several voltage supplies to find the most optimum value for the voltage supply to be used. The result shows that with the usage of 1 V voltage supply, the new design of multiplier using a combination of HFA and Vedic mathematics is able to produce the lowest power consumption and least delay time. The 4x4 bit Vedic multiplier is able to yield a full output voltage swing with a power consumption of only 0.2015 mW, delay of 376 ps and compact area of 3100 µm2

A 2x2 Bit Multiplier Using Hybrid 13T Full Adder with Vedic Mathematics Method

Various arithmetic circuits such as multipliers require full adder (FA) as the main block for the circuit to operate. Speed and energy consumption become very vital in design consideration for a low power adder. In this paper, a 2x2 bit Vedic multiplier using hybrid full adder (HFA) with 13 transistors (13T) had been designed successfully. The design was simulated using Synopsys Custom Tools in General Purpose Design Kit (GPDK) 90 nm CMOS technology process. In this design, four AND gates and two hybrid FA (HFAs) are cascaded together and each HFA is constructed from three modules. The cascaded module is arranged in the Vedic mathematics algorithm. This algorithm satisfied the requirement of a fast multiplication operation because of the vertical and crosswise architecture from the Urdhva Triyakbyam Sutra which reduced the number of partial products compared to the conventional multiplication algorithm. With the combination of hybrid full adder and Vedic mathematics, a new combination of multiplier method with low power and low delay is produced. Performance parameters such as power consumption and delay were compared to some of the existing designs. With a 1V voltage supply, the average power consumption of the proposed multiplier was found to be 22.96 µW and a delay of 161 ps

Antibacterial Efficacy of Zinc oxide nanoparticles against Serratia marcescens (ATCC 43862) and Enterococcus faecalis (ATCC 29121)

Zinc oxide nanoparticles (ZnO NPs) are a novel and alternative biomaterial for active biomedical applications among all metal and metallic oxide nanoparticles due to less toxicity and biocompatibility with human cells. In this study, we studied the growth curve of Serratia marcescens and Enterococcus faecalis to identify the mid-log phase of the bacterial growth to perform the exposure with ZnO NPs for investigating the antibacterial efficacy. The INT assay was used to determine the anti-bactericidal efficiency of ZnO NPs against S. marcescens and E. faecalis. The results showed that both the test bacteria attained the mid-log phase at the 5th hour. The determination of minimum inhibitory concentration (MIC) demonstrated a higher efficacy of ZnO NPs on the Gram-positive bacterium E. faecalis compared to the Gram-negative bacterium S. marcescens. The present study reports a higher susceptibility of Gram-positive bacterium over Gram-negative bacterium to the treatment of ZnO NPs

Experimental Investigation on Thermoelectric Chiller Driven by Solar Cell

This paper presents experimental explorations on cooling performance of thermoelectric chillers being driven by solar cells, as well as comparison results to the performance being driven by fixed direct current. Solar energy is clear and limitless and can be collected by solar cells. We use solar cells to drive thermoelectric chillers, where the cold side is connected to the water tank. It is found that 250 mL of water can be cooled from 18.5°C to 13°C, where the corresponding coefficient of performance (COP) is changed between 0.55 and 1.05, when solar insolation is changed between 450 W/m2 and 1000 W/m2. The experimental results demonstrate that the thermoelectric chiller driven by solar cell is feasible and effective for energy saving issues

PRL-3, a Metastasis Associated Tyrosine Phosphatase, Is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy

Combination with other small molecule drugs represents a promising strategy to improve therapeutic efficacy of FLT3 inhibitors in the clinic. We demonstrated that combining ABT-869, a FLT3 inhibitor, with SAHA, a HDAC inhibitor, led to synergistic killing of the AML cells with FLT3 mutations and suppression of colony formation. We identified a core gene signature that is uniquely induced by the combination treatment in 2 different leukemia cell lines. Among these, we showed that downregulation of PTP4A3 (PRL-3) played a role in this synergism. PRL-3 is downstream of FLT3 signaling and ectopic expression of PRL-3 conferred therapeutic resistance through upregulation of STAT (signal transducers and activators of transcription) pathway activity and anti-apoptotic Mcl-1 protein. PRL-3 interacts with HDAC4 and SAHA downregulates PRL-3 via a proteasome dependent pathway. In addition, PRL-3 protein was identified in 47% of AML cases, but was absent in myeloid cells in normal bone marrows. Our results suggest such combination therapies may significantly improve the therapeutic efficacy of FLT3 inhibitors. PRL-3 plays a potential pathological role in AML and it might be a useful therapeutic target in AML, and warrant clinical investigation

The TOP-SCOPE Survey of PGCCs: PMO and SCUBA-2 Observations of 64 PGCCs in the Second Galactic Quadrant

In order to understand the initial conditions and early evolution of star formation in a wide range of Galactic environments, we carried out an investigation of 64 Planck Galactic cold clumps (PGCCs) in the second quadrant of the Milky Way. Using the (CO)-C-13 and (CO)-O-18 J = 1-0 lines and 850 mu m continuum observations, we investigated cloud fragmentation and evolution associated with star formation. We extracted 468 clumps and 117 cores from the (CO)-C-13 line and 850 mu m continuum maps, respectively. We made use of the Bayesian distance calculator and derived the distances of all 64 PGCCs. We found that in general, the mass-size plane follows a relation of m similar to r(1.67). At a given scale, the masses of our objects are around 1/10 of that of typical Galactic massive star-forming regions. Analysis of the clump and core masses, virial parameters, densities, and mass-size relation suggests that the PGCCs in our sample have a low core formation efficiency (similar to 3.0%), and most PGCCs are likely low-mass star-forming candidates. Statistical study indicates that the 850 mu m cores are more turbulent, more optically thick, and denser than the (CO)-C-13 clumps for star formation candidates, suggesting that the 850 mu m cores are likely more appropriate future star formation candidates than the (CO)-C-13 clumps

The TOP-SCOPE Survey of PGCCs : PMO and SCUBA-2 Observations of 64 PGCCs in the Second Galactic Quadrant

In order to understand the initial conditions and early evolution of star formation in a wide range of Galactic environments, we carried out an investigation of 64 Planck Galactic cold clumps (PGCCs) in the second quadrant of the Milky Way. Using the (CO)-C-13 and (CO)-O-18 J = 1-0 lines and 850 mu m continuum observations, we investigated cloud fragmentation and evolution associated with star formation. We extracted 468 clumps and 117 cores from the (CO)-C-13 line and 850 mu m continuum maps, respectively. We made use of the Bayesian distance calculator and derived the distances of all 64 PGCCs. We found that in general, the mass-size plane follows a relation of m similar to r(1.67). At a given scale, the masses of our objects are around 1/10 of that of typical Galactic massive star-forming regions. Analysis of the clump and core masses, virial parameters, densities, and mass-size relation suggests that the PGCCs in our sample have a low core formation efficiency (similar to 3.0%), and most PGCCs are likely low-mass star-forming candidates. Statistical study indicates that the 850 mu m cores are more turbulent, more optically thick, and denser than the (CO)-C-13 clumps for star formation candidates, suggesting that the 850 mu m cores are likely more appropriate future star formation candidates than the (CO)-C-13 clumps.Peer reviewe

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake